Ko mouse phenotype database software

The impc database is a resource not only for the scientific community, but also for. Ko embryonic stem es cells, the eummcr has generated credriver es. The knockout mouse project komp is providing critical tools for understanding gene function and the genetic causes of human diseases. Comprehensive phenotyping through the international mouse phenotyping. The articles that report the behavior of the mouse strains that are maintained in the database are listed here. Mgimouse genome informaticsthe international database. Our data has such high resolution you can see vasculature in the liver, heart wall thickness, vilii in the bowel, the. Mammalian phenotype mp browser browse for a human disease term to find mouse models. We recently purchased a canabinoid receptor ko mouse strain to use for our experiments. Coordinated by the international mouse phenotyping consortium impc, an international coalition will produce and phenotype a total of 5,000 knockout mice by 2016. Software for the contextual and cued fear conditioning test was released. Disease connection search for a phenotype term to find relevant mutant genotypes.

Rescue of the spinal muscular atrophy phenotype in a mouse. The mouse phenotype database consists of the raw data of behavioral tests from the mice strain that are published in articles. Data records of tdo2 knockout mice were added to mouse phenotype database. Mouse strain phenotype database umlaut software, inc. Data records of trpm2 knockout mice were added to mouse phenotype database. Mouse genomic variation and its effect on phenotypes and. The phenotypesalleles project in mgi enables access to spontaneous, induced. Disease ontology do browser search or browse for a human phenotype term to find relevant human diseases with those phenotypes. Mouse phenotyping an overview sciencedirect topics. The knockout mouse phenotyping program komp2 collaborates with the international mouse phenotyping consortium impc to knockout and characterize all proteincoding genes in the mouse genome. C57bl6j age behavior database software for behavioral analysis.

The knockout mouse phenotyping program komp2 collaborates with the international mouse phenotyping consortium impc to knockout and characterize. Discover new roles of genes in cardiovascular physiology and disease. Established knockout mouse and phenotype database we have started providing more than 900 lines of knockout mouse and related database, which was produced by deltagen inc. The komp repository is the official archive and distribution center for the knockout mouse project komp, a major 5year transnih initiative designed to. Nice to see the new cell paper and the sanger links but anyone know how to get a list of the 250 mouse uniprot ids that have a phenotype. Nearly 8500 genes are targeted for deletion, most in a conditionalready format, by mutagenesis teams at csd childrens. We report genome sequences of 17 inbred strains of laboratory mice and identify almost ten times more variants than previously known. The komp repository is the official archive and distribution center for the knockout mouse project komp, a major 5year transnih initiative designed to generate null alleles in c57bl6 embryonic stem es cells for most genes not already available as knockout mice. The international mouse phenotyping consortium impc is a global effort to identify the function of every proteincoding gene in the mouse genome. List of deltagen and lexicon knock out mice available through repositories.

Diet effects on aortic lesion size in 103 hmdp strains that are transgenic for human apoe3leiden and human cetp f1. Nih knockout mouse phenotyping program komp2 and impc. Our new tool set is built using r statistical software, python and d3 visualizations. The mouse phenotype database consists of the raw data of behavioral tests from. Human disease ontology do hints for using and, or, and not, quotes, partial word matching. Knockout mouse phenotyping program komp2 highlights opening a soft. Spinal muscular atrophy is an autosomal recessive disease of motor neurons caused by lack of the smn gene. Our growing catalogue of mammalian gene function is freely available for researchers.